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Old September 10th 17, 08:21 PM posted to alt.sys.pc-clone.dell
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Default Problem saving screen profile file.

Go to system32 and locate the Spyder profile. Rename it (just add a .bak) a pop up will appear saying impossible to rename and will indicate the program that is using it (for me it was Google photo uploader). Close this program, run Spyder again and enjoy